Brain. Breath. Body.
Beta-hydroxybutyrate (BHB) interacts with misfolded proteins
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : dimanche 8 décembre 2024 10:57
Hypnose et anesthésie en 2019 : de la neuroscience au bloc opératoire Hypnosis and anaesthesia: What's old, what's new?
- Détails
- Catégorie : Hypnosis, cognitive hypnotherapy
- Publication : dimanche 8 octobre 2023 11:23
L'hypnose offre une perspective de soins non pharmacologiques
reconnue et adaptée à de nombreuses situations. Le bénéfice
principal tient à la capacité à moduler la douleur, ouvrant le
champ à l'hypnoanalgésie. Technique non médicamenteuse,
elle va dans le sens d'une iatrogénie minimale, d'une fluidité
des procédures et d'une réhabilitation rapide. Elle accompagne
l'évolution actuelle des techniques anesthésiques, de plus en
plus fines, ciblées et réversibles.
https://www.sciencedirect.com/science/article/abs/pii/S2352580019301650
The Effect of a Ketogenic Diet (vs a Carbohydrate-Based Diet), on Cognitive Performance, Mood and Subjective Sleepiness during 36 Hours of Extended Wakefulness
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : lundi 5 décembre 2022 15:02
The Effect of a 2-Week Ketogenic Diet, versus a Carbohydrate-Based Diet, on Cognitive Performance, Mood and Subjective Sleepiness during 36 Hours of Extended Wakefulness in Military Personnel
The KD appeared to improve cognitive performance, mood and sleepiness during 36 h of extended wakefulness compared with the CHO-based diet. This suggests the KD could be considered for military operations when sleep deprivation is anticipated.
Abstract Open Access
https://www.mdpi.com/2673-9992/9/1/22
Wim Hof Method and inflammation 2022 study
- Détails
- Catégorie : Respiration et Froid / Breathwork and Cold Exposure
- Publication : mercredi 16 mars 2022 14:24
It has been shown that practicing the Wim Hof Method can reduce acute inflammation. A new study has just been published on this subject. Not only does it confirm the previous data, but it also shows that the breathing technique is the most important factor in reducing inflammation. Combined with breathing techniques, cold exposure training seems to reinforce the effects of the latter. However, cold exposure training alone has little effect on this inflammation protocol. On the other hand, voluntary cold training seems to have an effect on the severity of flu-like symptoms.
(French: Il avait été montré que la pratique de la Méthode Wim Hof permet de diminuer une inflammation aigüe. Une nouvelle étude vient de paraître sur ce sujet. Non seulement, elle confirme les données précédentes, mais permet de comprendre que la technique respiratoire est la principale responsable de la diminution de l’inflammation. Associé à la technique respiratoire, l’entraînement à l’exposition au froid semble renforcer les effets de celle-ci. Mais pratiqué seul, il a peu d’effet sur l’inflammation. En revanche, l’entraînement à l’exposition volontaire au froid semble agir sur la sévérité des symptômes de type grippal.)
Link to article by Sebastien Zappa: (French and English: https://respire-aligne.com/wim-hof-method-and-inflammation-breathing-cold-both)
Link to 2022 Study:
The effects of cold exposure training and a breathing exercise on the inflammatory response in humans
Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : mardi 29 juin 2021 06:31
"We have demonstrated the metabolic effects of elevated circulating ketone bodies as a fuel and biological signal to create a unique physiological condition. Ketosis may alter substrate competition for respiration, while improving oxidative energy transduction under certain conditions, such as endurance exer-cise. Consequently, nutritional ketosis may help to unlock greater human metabolic potential."
https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(16)30355-2
Metabolic characteristics of keto-adapted ultra-endurance runners
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : mardi 29 juin 2021 06:21
In summary, these results provide the first documentation of the metabolic adaptations associated with long-term con- sumption of a very low-carbohydrate/high-fat diet in highly trained keto-adapted ultra-endurance athletes. The enhanced ability to oxidize fat during exercise across a range of intensities is striking, as is the ability to maintain “normal” glycogen concentrations in the context of limited carbohydrate intake. Keto-adaptation provides an alternative to the supremacy of the high-carbohydrate paradigm for endurance athletes.
https://www.metabolismjournal.com/article/S0026-0495(15)00334-0/fulltext
Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : mardi 29 juin 2021 06:02
"The NAD+ requirement of the glycolytic and ketolytic pathways is illustrated in Figure 3. Glycolysis requires 4 NAD+ to make 2 Acetyl-CoA, while ketolysis consumes no NAD+ to make Acetyl-CoA from AcA, and only one NAD+ to convert BHB to AcA (6). This is to the best of our knowledge the first interventional study that shows that ketones can have a NAD+ sparing effect in healthy human brain."
https://www.frontiersin.org/articles/10.3389/fnut.2018.00062/full
Notable Limitation: funded by Nestlé.
Appetite suppression through smelling of dark chocolate correlates with changes in ghrelin in young women
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : mardi 22 décembre 2020 03:45
The objective of this study is to explore the relationship between appetite and levels of gastrointestinal hormones after smelling chocolate and after melt-and-swallow 30 g chocolate (1.059 oz, 85% cocoa, 12.5 g of sugar per 100 g product).
(...)
In conclusion, this study shows that appetite was suppressed after smelling or ingesting dark chocolate. The satiation effects after smelling seems to find its biological basis in the involvement of ghrelin, possibly mediating vagal tone. Satiating food odors are therefore challenging to study further and may be of medical interest by influencing appetite in clinical conditions.
Resistance to Symptomatic Insulin Reactions after Fasting
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : mercredi 9 décembre 2020 05:50
"This study was carried out to determine if ,in fasting, an adaptation to utilization of ketones could prevent cerebral dysfunction during periods of acute, insulin-induced glucopenia."
"After fasting two months, administration of weight-adjusted doses of insulin (...) glucose concentrations as low as 0.5 mmol/l (9mg/100ml) failed to precipitate hypoglyemic reactions."
Brain Fuel Ketones... Fuel metabolism in starvation (George F Cahill)
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : mercredi 9 décembre 2020 05:34
Brain substrate utilization in three fasting obese volunteers after several weeks of starvation switches from 100% Glucose to 70% Ketones.
"Many studies suggest human brain cells can survive with little to no glucose, but proving the point is difficult as well as experimentally difficult and ethically questionable."
And also interesting:
"Not well known, however, is the metabolism of the human newborn, which is essentially ketotic. Blood glucose levels fall strikingly in the neonate, and con- centrations of βOHB may rise to 2–3 mM. The newborn human brain consumes 60%–70% of total metabolism at birth, nearly half via β-hydroxybutyrate. Fitting in with this pattern is maternal colostrum. It contains much triglyceride and protein, but little lactose, starting man’s entry into society on an Atkins diet (Figure 6)!"
Ketogenic Diet Modulates NAD+-Dependent Enzymes and Reduces DNA Damage in Hippocampus
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : mardi 8 décembre 2020 20:19
"Here rats were fed ad libitum regular chow or KD for 2 days or 3 weeks and the levels of hippocampal sirtuins, PARP-1, and the oxidative DNA damage marker 8-hydroxy-2’-deoxyguanosine were quantified. We found a significant immediate and persistent increase in the collective activity of nuclear sirtuin enzymes, and a significant augmentation of Sirt1 mRNA at 2 days."...
"Our data show that a KD can rapidly modulate energy metabolism by acting on NAD+-dependent enzymes and their downstream pathways. Thus, therapy with a KD can potentially enhance brain health and increase overall healthspan via NAD+-related mechanisms that render cells more resilient against DNA damage and a host of metabolic, epileptic, neurodegenerative, or neurodevelopmental insults."
"Here we determined that KD increased NAD+, decreased levels of DNA damage and induced rapid changes in PARP-1 and sirtuin enzymes. This cohort of changes induced within 2 days of KD exposure could thus be protective for healthy cells against oxidative and metabolic damage and provide key mechanisms rendering KD beneficial across a range of neurological conditions."