Appetite suppression through smelling of dark chocolate correlates with changes in ghrelin in young women
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : mardi 22 décembre 2020 03:45
The objective of this study is to explore the relationship between appetite and levels of gastrointestinal hormones after smelling chocolate and after melt-and-swallow 30 g chocolate (1.059 oz, 85% cocoa, 12.5 g of sugar per 100 g product).
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In conclusion, this study shows that appetite was suppressed after smelling or ingesting dark chocolate. The satiation effects after smelling seems to find its biological basis in the involvement of ghrelin, possibly mediating vagal tone. Satiating food odors are therefore challenging to study further and may be of medical interest by influencing appetite in clinical conditions.
Resistance to Symptomatic Insulin Reactions after Fasting
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : mercredi 9 décembre 2020 05:50
"This study was carried out to determine if ,in fasting, an adaptation to utilization of ketones could prevent cerebral dysfunction during periods of acute, insulin-induced glucopenia."
"After fasting two months, administration of weight-adjusted doses of insulin (...) glucose concentrations as low as 0.5 mmol/l (9mg/100ml) failed to precipitate hypoglyemic reactions."
Ketogenic Diet Modulates NAD+-Dependent Enzymes and Reduces DNA Damage in Hippocampus
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : mardi 8 décembre 2020 20:19
"Here rats were fed ad libitum regular chow or KD for 2 days or 3 weeks and the levels of hippocampal sirtuins, PARP-1, and the oxidative DNA damage marker 8-hydroxy-2’-deoxyguanosine were quantified. We found a significant immediate and persistent increase in the collective activity of nuclear sirtuin enzymes, and a significant augmentation of Sirt1 mRNA at 2 days."...
"Our data show that a KD can rapidly modulate energy metabolism by acting on NAD+-dependent enzymes and their downstream pathways. Thus, therapy with a KD can potentially enhance brain health and increase overall healthspan via NAD+-related mechanisms that render cells more resilient against DNA damage and a host of metabolic, epileptic, neurodegenerative, or neurodevelopmental insults."
"Here we determined that KD increased NAD+, decreased levels of DNA damage and induced rapid changes in PARP-1 and sirtuin enzymes. This cohort of changes induced within 2 days of KD exposure could thus be protective for healthy cells against oxidative and metabolic damage and provide key mechanisms rendering KD beneficial across a range of neurological conditions."
Brain Fuel Ketones... Fuel metabolism in starvation (George F Cahill)
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : mercredi 9 décembre 2020 05:34
Brain substrate utilization in three fasting obese volunteers after several weeks of starvation switches from 100% Glucose to 70% Ketones.
"Many studies suggest human brain cells can survive with little to no glucose, but proving the point is difficult as well as experimentally difficult and ethically questionable."
And also interesting:
"Not well known, however, is the metabolism of the human newborn, which is essentially ketotic. Blood glucose levels fall strikingly in the neonate, and con- centrations of βOHB may rise to 2–3 mM. The newborn human brain consumes 60%–70% of total metabolism at birth, nearly half via β-hydroxybutyrate. Fitting in with this pattern is maternal colostrum. It contains much triglyceride and protein, but little lactose, starting man’s entry into society on an Atkins diet (Figure 6)!"
Ketogenic Diet + Intermittent fasting as potential prophylactic strategy and adjuvant therapy to combat SARS-CoV-2 infections
- Détails
- Catégorie : Ketogenic Diet / Healthy diet
- Publication : mardi 8 décembre 2020 18:34
"Key Message: A diet regimen of ketogenic breakfast along with supplementation with two doses of lauric acid-rich MCTs at breakfast and lunch times, followed by 8–12-h IF and a dinner rich with fruits and vegetables, could be a potential prophylactic strategy and adjuvant therapy to combat SARS-CoV-2 infections."
"With the gradual opening after long lockdown because of the COVID-19 pandemic, we are proposing a prophylactic diet regimen that may limit viral levels in the human body. This can be established by switching the host lipid metabolism, critical for viral replication and assembly, by induction of the ketogenic pathway using coconut-rich MCFAs along with olive oil, followed by 8–12 h fasting and a dinner rich with fruits and vegetables."
review article Received: July 15, 2020 Accepted: July 26, 2020 Published online: September 18, 2020